Multi-site implementation of whole genome sequencing for hospital infection control: A prospective genomic epidemiological analysis

NL Sherry; CL Gorrie; JC Kwong; C Higgs; RL Stuart; C Marshall; SA Ballard; M Sait; TM Korman; MA Slavin; RS Lee; M Graham; M Leroi; LJ Worth; HT Chan; T Seemann; ML Grayson; BP Howden

Journal article

Multi-site implementation of whole genome sequencing for hospital infection control: A prospective genomic epidemiological analysis

NL Sherry, CL Gorrie, JC Kwong, C Higgs, RL Stuart, C Marshall, SA Ballard, M Sait, TM Korman, MA Slavin, RS Lee, M Graham, M Leroi, LJ Worth, HT Chan, T Seemann, ML Grayson, BP Howden

Lancet Regional Health Western Pacific | ELSEVIER | Published : 2022

DOI: 10.1016/j.lanwpc.2022.100446

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Abstract

Background: Current microbiological methods lack the resolution to accurately identify multidrug-resistant organism (MDRO) transmission, however, whole genome sequencing can identify highly-related patient isolates providing opportunities for precision infection control interventions. We investigated the feasibility and potential impact of a prospective multi-centre genomics workflow for hospital infection control. Methods: We conducted a prospective genomics implementation study across eight Australian hospitals over 15 months (2017,2018), collecting all clinical and screening isolates from inpatients with vanA VRE, MRSA, ESBL Escherichia coli (ESBL-Ec), or ESBL Klebsiella pneumoniae (ESBL-..

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University of Melbourne Researchers

Norelle Sherry Author

Claire Gorrie Author

Jason Kwong Author

Caroline Marshall Author

Related Projects (1)

IMPROVING PREVENTION, TRACKING AND TREATMENT OF MAJOR HUMAN BACTERIAL PATHOGENS

This research fellowship will lead to a detailed understanding of the mechanisms by which bacteria become resistant to antibiotics and cause..

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Awarded by University of Melbourne

Funding Acknowledgements

Melbourne Genomics Health Alliance (supported by State Government of Victoria, Australia), and National Health and Medical Research Council (Australia).